Abstract: Excellent structural form can reduce vibration impact on the equipment in its operational environment, effectively protecting the delicate electronic components inside the equipment and ensuring its long-term stable performance. A mechanical analysis and optimization design of the sheet metal chassis is conducted in this paper. The optimization objectives and the inherent vibration characteristics of the chassis are clarified through simulation analysis. Subsequently, measures such as weight reduction of the heat sink and reinforcement of the chassis baseplate are implemented, significantly reducing the stress on the main chip. This topology optimization method based on vibration characteristics can complete design optimization more efficiently and shorten the solution cycle of topology optimization in finite element software, obtaining a reasonable solution that meets design requirements and possesses considerable practical value.