Abstract: Traditional processing methods like stamping dies for indium sheet are inefficient and unable to meet the requirements of large-scale production. Laser cutting, as a non-contact machining method, is particularly suitable for processing of foil-like metallic materials like indium sheet. In this paper, the key technologies of laser cutting for indium sheet are systematically studied, the effects of different cutting parameters on cutting quality are analyzed and corresponding measures for critical technologies are taken, including process parameter optimization, cutting path planning and efficient removal of residual material. Key process parameters such as laser power and cutting speed are optimized through orthogonal experiments. Taking typical indium sheet part as the research object, the cutting path is reasonably optimized based on the principles of minimizing empty travel and avoiding repeated cutting. Additionally, a nesting cutting method is proposed, which has effectively resolved the issue of low efficiency in removing residual material. Using the processing method developed in this paper, indium sheet can be processed with significantly improved efficiency while ensuring high-quality results and the requirements for high-quality and efficient batch production of indium sheet are satisfied.