Abstract: As the use area of military electronic equipment is wide and the environmental conditions are different, the environmental worthiness problems are becoming more and more serious. Environmental worthiness design of the electronic plug-in board in military equipment is introduced in this paper, including thermal design, electromagnetic compatibility design, vibration-proof, impact prevention design, and "three-prevention" design. Through improving the basic component units adaptation ability to climate, mechanical, electromagnetic and bio-chemic environments, the environmental worthiness of the whole equipment will be enhanced.