Abstract: Optimization design method based on reliability and its application to structure design of cockpit display and control device are presented in this paper．The capability improvement of anti-vibration and heat transformation can be achieved by optimization design of unsubstantial parts detected by vibration analysis and thermal analysis．Reliability of cockpit display and control device can be guaranteed based on reliability analysis and optimization．The effectiveness of this optimization method has been proved by the tests for environment adaptability and reliability parameters．