Abstract: The structure system design of a spacecraft electronic equipment is introduced in this paper. According to the characteristics of satellite installation platform and related technical requirements, the design methods and ideas of overall structure design, thermal design,vibration prevention,EMC,TID prevention,and so on are described,and the difference between structural design of spaceborne electronic equipment and general electronic equipment structure design is understood,the "satelliterization" of structural design is realized. Combined with the engineering experience of model design, the lightweight structure configuration, the high-power FPGA chip cooling, and the anti-radiation reinforcement technology are studied. The design methods and ideas can be used for references.