Abstract: In this paper, the optimization design of typical assembly frame of airborne electronics equipment under random vibration is studied by numerical and experimental methods. Firstly, the random vibration load is transformed into static load by the idea of static equivalence, and then the topology optimization is conducted for the frame under static load. Then, the model design and the dynamics simulation analysis are carried out based on the topology optimization results. The analysis results show that the strength and stiffness of the optimized frame are both improved significantly under the condition that the weight of the optimized frame is not larger than that of the original one. Finally, the feasibility of the optimization design is verified through random vibration test.