Abstract: To solve the high weight ratio problem of a hand throw UVA (Unmanned Aerial Vehicle) wing structure, a multivariable structure topology optimization design method is proposed. The method, which optimizes the target with minimum structure weight, takes the air dynamic force computed by Fluent as the load input conditions, takes the max displacement, max strain and buckling eigenvalue calculated by Nastran as restrain and takes wing structure size as optimization variable. The structure performance simulation results show that after the optimization, the structure weight is reduced by 21.7% which meets structure safety constraints and can improve the cruise time 38% and increase payload by 278 g. Meanwhile, the change law of the optimization variable can also provide reference for the structure design of this type of aircraft.