Abstract: To achieve the whole process through from design, process to manufacture based on the unified 3D model is an important development direction of the structural and process digital mock-up of complex electronic equipment. It is of great significance to improve the development quality, shorten the product period and reduce the design errors. The subsistent problems in the design process of complex electronic equipment are analyzed and a new design mode based on the unified digital prototype model from design to manufacture is put forward in this paper on the basis of development characteristics of complex electronic equipment. Meanwhile, the technologies such as integrated design platform construction, model definition, model transmission, collaborative simulation are studied deeply. The whole process through from design, process to manufacture based on the unified 3D model is achieved and applied to engineering practice. It has great reference value to promote the design mode innovation of complex electronic equipment.