Abstract: The traditional design of prestressed cable-truss antenna structure used to depend on the empirical design and non-gradient method. In order to improve the optimization design efficiency of this kind of structure, a topology optimization method for the prestressed cable-truss structure under large deformation conditions is proposed in this paper. This method takes a kind of compliance index modified by prestress as the objective function, the mass fraction and strength as the optimization constraints and obtains the continuous design variables through the normalization method. Finally, the overall optimization design for the topological configuration, structural size and prestress value of the cable-truss structure is achieved. The sensitivity information of the objective function can be obtained completely by the analytical method. The numerical results show that the method has good applicability to the optimization design of prestressed cable-truss antenna under both single and multiple load cases under large deformation conditions.