Abstract: Compared with traditional liquid cooling systems, two-phase flow cooling systems not only prevent metal chips, oil stains and other impurities from remaining in the cold plate flow channel, but also add water removal requirements to prevent water from freezing and blocking the flow channel in low-temperature environments. The cold plate flow channel has complex layout and blind area, making it extremely difficult to remove water. In-depth research on the techniques of water removal is conducted in this paper. The residual water in the cold plate flow channel is continuously boiled and vaporized by heating and vacuumizing to reach the goal of water removal. The proper process parameters are determined by theoretical research and experimental analysis. Experiment results show that the techniques are feasible and can improve the overall reliability of the product cooling system effectively.