Abstract: Cooling plate components are widely used in modern electronic equipment. The flow channels of cooling plate are arranged densely with complex structure. Once the internal cleanliness is out of control, failures such as blockage and leakage of the cooling system will occur and the normal operation of electronic equipment will be affected seriously. In order to improve the sealing performance and the operation reliability of the cooling system, the research on the whole process pollution control technology is conducted for the high risk parts of the manufacturing process of the liquid cooling plate, including machining process protection technology, efficient cleaning technology and flow channel cleanliness detection technology. Test verification and electronic equipment development practice indicate that the control method can effectively control the machining chip, oil, cutting fluid and other types of pollutant residues and thus effectively improve the overall cleanliness of the cooling system.